The hormone leptin regulates food intake and body weight. It can cross the blood

The hormone leptin regulates food intake and body weight. It can cross the blood-brain barrier. Search PubMed (www.pubmed.gov (Links to an external site.)) for blood-brain barrier and leptin and select two original research articles about leptin. Summarize the results of these articles. Which proprieties of leptin allow it to cross the blood-brain barrier? How does leptin regulate energy balance? 

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