Guiding question: How can tools and approaches used to examine the exposome help

Guiding question: How can tools and approaches used to examine the exposome help
us determine mechanistic relationships between environmental exposures and health
effects?
Read What is new in the exposome?. Also skim at least one of Use of the “Exposome”
in the Practice of Epidemiology or Applying the exposome concept in birth cohort
research.
Using and appropriately crediting ideas from these articles and the asynchronous
content, discuss how incorporating exposome concepts/approaches can affect choices
related to each of the following:
• Research questions
• Exposure definitions and measurement methods
• Outcomes
• Study populations
• Study designs
• Timing of studies
• Statistical analyses
Next, thinking about how we assess mechanistic relationships between environmental
exposures and health outcomes, identify at least one advantage, one opportunity, and
one challenge in incorporating exposome concepts/approaches for each of the
following:
• Understanding absorption, distribution, metabolism, and excretion of environmental
toxicants
• The role of biomarkers
• Integrating multiple -omics types
• Identifying causal questions and/or well-defined research questions
• Describing causal pathways
• Identifying and/or assessing interactions among environmental factors
Your answers may be presented in tabular and/or narrative format

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